Deconstructing thermodynamic parameters of a coupled system from site-specific observables
نویسندگان
چکیده
منابع مشابه
Deconstructing thermodynamic parameters of a coupled system from site-specific observables.
Cooperative interactions mediate information transfer between structural domains of a protein molecule and are major determinants of protein function and modulation. The prevalent theories to understand the thermodynamic origins of cooperativity have been developed to reproduce the complex behavior of a global thermodynamic observable such as ligand binding or enzyme activity. However, in most ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1003609107